# The act or procedure of sterilizing. # The condition of being sterile or sterilized. Heat sterilization of medical instruments is known to have been used in ancient Rome, but it mostly disappeared throughout the Middle Ages resulting in significant increases in disability and death following surgical procedures. Preparation of injectable medications and intravenous solutions for fluid replacement therapy requires not only a high sterility assurance level, but well-designed containers to prevent entry of adventitious agents after initial sterilization. == ==
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