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The connection between diuretics and hyperglycemia involves intracellular K+ levels. Intracellular K+ is involved in the secretion of a lot of hormones...including insulin. Some diuretics cause hypokalemia, (decrease in K+). This inhibits insulin secretion and can lead to hyperglycemia. It's not really a problem unless the patient is pre-diabetic. In that case, it is significant enough to push them over to Diabetes. Hope this helped!

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โˆ™ 2008-08-27 00:27:09
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Q: How diuretics cause hyperglycemia?
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