answersLogoWhite

0

According to Drugs.com GENERALLY AVOID: Due to its serotonergic activity, coadministration of tramadol with serotonin-enhancing drugs such as SSRIs, SNRIs, nefazodone, trazodone, and mirtazapine may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea. Patients receiving tramadol with serotonin-enhancing drugs may also have an increased risk of seizures due to additive epileptogenic effects of these agents.

MANAGEMENT: In general, the use of tramadol in combination with highly serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Patients should be closely monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. The potential risk for serotonin syndrome should be considered even when administering serotonergic agents sequentially, as some agents may demonstrate a prolonged elimination half-life.

User Avatar

Wiki User

16y ago

What else can I help you with?

Related Questions

Is it ok to Trazodone and Adderall mix?

I take adderall 60 mg, 30 in the morn and 30 about 1pm and trazadone 100mg at night


If i take trazodone and Effexor and adderall and xanex and lorcet will that show up on a drug test.?

Yes.


Can Benadryl be taken with Paxil and trazadone?

Can I take benzonatate and trazodone together


Can i take fioricet and adderall together?

yes you can!


Can you take Concerta Oral and trazodone together?

Absolutely not! That is a severe drug interaction.


Can you take Cipro and Adderall together?

yes you can, i am prescribed 15mg adderall xr and my obgyn prescribed me cipro 500mg. I asked my pharmacist to make sure i could take them together or if i should wait a little while after i took the adderall to take the cipro and he said that it is ok to take them together.


Can you take ultram flexeril and adderall together?

Yes


Can you take one benadryl and one trazodone?

I would not suggest taking two sedatives together.


Can you take trazodone while taking Prozac?

Yes, if both are prescribed for you, there is no problem in taking those 2 drugs together. To get the "sleeping" effect of trazodone, without interfering with prozac antidepressant effect, the trazodone dosage should be around 25mg to 100mg.


Can you take acetaminophen while taking trazodone?

yes acetominophen will not interact with trazodone it is safe to take togather


When is the best time of day to take trazodone?

Since trazodone causes drowsiness, it is often used as a sleep aid making the best time to take trazodone before bed. Trazodone is best absorbed when taken with food.


Can you take abilify adderall lamictal and tramadol together?

maybe you can maybe you cant