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I started taking Lanzaprozole after being stable on warfarin for 6 months. My INR went from 2.5 to 5.8 and I had bleeding issues. Your INR needs to be checked a few days after starting and weekly until it settles.

The above answer is correct in indicating you should use caution. To answer your question directly, the answer is yes, you can take them together. There are several interactions with the above list, but your provider should be aware of them and should have made you aware of what to look for. You are on 3 anti-coagulation medicines so naturally they will increase the anticoagulation effect more than any one by itself. This should be considered and intended as with the above profile you have probably had, or are at high risk for, a thrombotic (clotting) event.

The lansoprazole can increase the effect of warfarin as the original answerer experienced and yes, you should be monitored carefully to make appropriate adjustment to maintain your target INR.

Crestor can also potentially increase the effect of warfarin but if you are monitoring your INR due to one drug, you are automatically including all others (since the INR doesn't care how many effect it, as long as it is adjusted properly).

Lastly there is a minor concern with lansoprazole (PPI) and Crestor (statin) together. The PPI can increase the risk of muscle damage when taking a statin (called rhabdomyolysis) but the combination of PPI and statin is questionable. There are several of each type of drug to choose from and issues have been noted with some combinations. Because of this, the warning is expanded to include all of the related drugs. If you don't experience the side effects you've probably already been warned about (tender/painful muscles in the calves or thighs is most common) then you are likely OK.

Your biggest concern should always be your blood thinners, and especially warfarin because so many things can effect it. The important thing is consistency. Yes, these drugs can effect your INR, but that INR can be adjusted by adjusting your warfarin dose. This will make up for those added effects. As long as you then stay consistent (keep taking those meds, keep a regular diet, don't add new herbal supplements) then your INR should remain steady. Consistency is the key once you reach your INR goal. When any changes are made to your medicines then further monitoring and possible adjusting of your warfarin may be needed.

When taking those anticoag meds, always be aware of signs of bleeding such as blood from your gums while brushing, excess bruising, and blood in urine or stool, etc. Also, if you do get injured, even if it's a small cut, and you are having trouble stopping the bleeding yourself, don't feel bad about going to the ER. They can stop the bleeding for you and while the cut might not seem like an emergency, the bleeding can be.

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13y ago
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13y ago

Yes. Be sure to take each only as directed, and follow your prescriber's instructions for follow-up blood tests.

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10y ago

can you take coversyl and crestor at the same time

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14y ago

Yes, and these medications are not uncommonly prescribed together.

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10y ago

Metformin

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Q: Can you take omeprazole and crestor at the same time?
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