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Yes, lymph nodes can swell in response to irritation caused by tobacco smoking. Repeated damage in chronic tobacco smoking habits can lead to swollen lymph nodes. Lymph nodes swell due to increase WBC and lymphocyte activity, as nodes are activated to clear out dead cells and attack cells that may have damaged DNA. Some of these damaged cells may be pre-cancerous or cancerous. This condition can lead to a variety of cancers including lymphoma.

Regular irritation causes many different neck glands to react to the damage, thereby causing activity in the immune system leading to the swelling. Lymphocytes and related cell macrophages will drain into the node in the neck if damage is occurring in the upper respiratory system (trachea, upper bronchial tract, throat, near hyoid bone). A network of cervical lymph nodes spans the neck and lower jaw, and "overload" of one node can cause nearby nodes to swell. "Blisters" in the mouth can also occur, as small glands on the inside of the mouth (called "submandible" lymph nodes) swell in response to immune system activity.

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12y ago
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16y ago

No. Swollen lymph nodes are the sign of an infection. See a doctor.

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Q: Can smoking cause swollen lymph nodes in the neck?
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