John Wayne died of cancer of the stomach and lungs.
Some believe he was exposed to radioactive fallout when he was filming "The Conqueror"; as the film site was near a nuclear testing ground. However it is more likely that his cancer was a result of the fact that he was a heavy smoker.
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He passed away at the University of California Los Angeles Medical Center on June 11, 1979 at approximately 5:30 in the afternoon.
he had cancer
In a strange twist of fate in his last movie, "The Shootist", he played an aging gunfighter with cancer.