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Down syndrome happens by the splitting of the chromosomes. It is not a genetic disease. It is a chromosomaldisorder.

Chromosomal changes like duplications or translocations1 occur in only one sex cell. A baby normally inherits 23 chromosomes from each parent to make a total of 46 chromosomes in 23 identifiable pairs.

In Down Syndrome, an extra (duplicated) chromosome number 21 is inherited from either the father or the mother, to make a total of 47 chromosomes (23 pairs plus 1) in every cell of the DS child. (DS is also called Trisomy 21 ) DS is usually inherited from the mother, and the major risk of DS is the age of the woman at conception.

1A duplication is an extra copy of a chromosome (or part of a chromosome) - a translocation is an extra bit of chromosome sticking onto another chromosome.

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11y ago
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12y ago

Down Syndrome (Not 'Down's') occurs when a gene has the wrong number of alleles. There are many such birth defects that never show up because your body has a large tolerance for small differences. Not so in Down Syndrome, though.

Down syndrome occurs anywhere, and is more prevalent the older a woman is when she gets pregnant.

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14y ago

In 5% of Down syndrome cases, a translocation that occurred in previous generations between Chromosome 21 and 14 is the cause.

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12y ago

One of the times a mutation causing down syndrome can occur is during meiosis, when the ovum becomes a zygote. Sorry I don't know more.

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schockemma

Lvl 8
4y ago

Down syndrome is caused by nondisjuntion which is an issue faced during cell division. A person with down syndrome ends up having 3 copies of chromosome 21 instead of 2.

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12y ago

an extra copy of chromosome 11

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8y ago

An extra 21 chromosome.

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Q: What chromosomal abnormality causes Down syndrome?
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Related questions

Is anyone susceptible to this Down syndrome?

no, it is a chromosomal abnormality, not a contagious disease.


What is the most common chromosomal abnormality in humans?

Trisomy 21, Down's syndrome


What gene is affected in Down Syndrome?

It is the result of a chromosomal abnormality, in which there is an extra chromsome on the chromosome 21 pair. This is call trisomy 21.


What is meant by chromosomal abnormality?

Chromosomal abnormality is a broader term, describing duplications, loss, gain etc, of a particular chromosome. More related to the structures in an ideogram.Genetic disorder is a much broader term that describes any chromosomal or genetic changes. A disease condition.


Why do people call Down Syndrome Down's?

Down syndrome is the correct term. People who are using "Downs" are speaking incorrectly. Down syndrome used to be called Down's syndrome, but since John Langdon Down did not have nor "invent" this chromosomal abnormality, the correct name is Down syndrome. Countries such as the UK, still use the term Down's syndrome, but shortening it to Down's is not using people first language, therefore, it is incorrect.


What are the Characteristics of abnormality?

down syndrome


How do you get Down syndrome?

You do not "get" Down's syndrome. You are born with it. It is a chromosomal condition of the 21st chromosome.


What are the chromosomal aberrations of Down syndrome?

There is no actual chromosomal change, there is an extra chromosome.


What is the most common chromosomal abnormality seen in live born babies what is the prevalence of this disorder what is the relationship between maternal age and the risk of having a baby with this?

Down Syndrome-the rest is on wikipedia


Is down syndrome communicable disease?

No. Down's syndrome is a chromosomal disorder. In order to have it you have to be born with it.


What are some chromosomal disorders?

The most common type of chromosomal disorder is the Down syndrome caused by an added copy of chromosomes 21. More common chromosomal disorders are Klinefelter's syndrome and Turnerâ??s syndrome.


What could be described as a chromosomal mutation?

Chromosomal mutation can have lasting impacts on the person who this happens to. A version of a chromosomal mutation is the mutation that leads to Down's Syndrome.