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Q: What are the long term effects of taking an upper with a downer?
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lorazapam and claritin can be mixed as long as the claritin does not contain any decongestant ie psudophedrine. that's like taking a strong "downer" with a strong "upper"


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Taking drugs is not safe. If your question is whether your going to die or not, it depends on the amount of coke and Valium you take at once. Your body will only be able to handle a certain dosage of each drug at one time. Also taking coke and Valium for long term use your body and mind eventually will brake down, and you will die. If your question is whether cannabis is making the coke and/or Valium worse for you, the answer is no, it makes no difference whether you smoked pot or not, your still just as unsafe using coke and/or Valium alone. However the effects of the drugs may change due to the effects of pot. Because cocaine is and upper, smoking the downer marijuana may cancel out the effects of the cocaine depending on how strong either drug is. Smoking cannabis isn't unsafe unless you make it unsafe.


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I would guess that the long term effects are similar to Marijuana. The same chemical reaction is taking place. You will ultimately begin to lose memory and become mentally slower.