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This is tricky because, believe it or not, there are potentially as many atoms in a grain of sand as their are stars in the entire universe. But, here goes.

Sand is made up of Silica, which has the formula SiO2

silicon weighs 28 atomic units

Oxygen weighs 16 atomic units

so each SiO2 weighs 60 atomic units

There are 6.023 x 1023 atomic units in a gram. that is 6 with 23 zeros after it.

So there would be 6.023 x 1023 / 60 = 1x 1022 SiO2s in a gram, so 3 x 1022 atoms in a gram.

Say a grain of sand is 1mm across it has a volume of 0.001cm3;1cm3 of sand weighs about 2.6g, so a grain of sand will weigh 0.0026g.

So, to find the number of atoms in a grain of sand we multiply the number of atoms per gram by the number of grams:

3 x 1022 x 0.0026g = 7.8 x 1019 atoms

or

78,000,000,000,000,000,000.

Assuming you could count 2 atoms per second, it would take approximately 1,236,681,887,366 (1.2 Trillion) years.

Yes, really. If I were you I would try counting at least four every second, then it would only take 6.2 billion. You'd have a lot more free time.

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Q: How long would it take to count atoms in a grain of sand?
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