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Yes, by adding the Sea Foam through the vacuum line, the sea foam will distribute throughout all cylinders. As an added touch, also consider adding the remainder to your crankcase and fuel tank to clean fuel injectors :)

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Q: You want to pour some Sea Foam cleaner through the master cylinder vacuum hose of your GMC Sonoma while the engine runs to clean the fuel injectors directly--will doing so reach all six cylinders?
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