What is methotrexate?

Answer 1

Source: rx2040. com

Methotrexate is an antimetabolite used to treat certain types of cancer.

Methotrexate is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.

Methotrexate is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, Cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.

Answer 2

Originally methotrexate was given in massive doses in chemotherapy in the treatment of cancer. However it was found a result those relatively small doses of methotrexate can cause enough of a change in the immune system to stop it from causing the inflammation that is Rheumatoid Arthritis. Methotrexate is now seen as the gold standard in the treatment of Rheumatoid arthritis. It has to be administered with care though along wit folic acid supplements because it depletes folic acid and can bring about kidney toxicity

Answer 3

It's a drug used for the treatment of cancer rheumatoid arthritis and other diseases.

Answer 4

Methotrexate is used to treat several forms of cancer, as well as some autoimmune diseases.

Answer 5

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