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They never met face to face. They first confronted each other on the battlefield of Issus in 333 BCE. Their next encounter was the battle of Gaugamela in 331 BCE. Darius lost both, and was assassinated by his own nobility after the second one. Alexander, pursuing after the battle, got to see Darius' murdered corpse.

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Q: Where did Alexander the Great and Darius 3 have their first meeting?
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