Dis-comfort
The prefix is 'ap'.
UNfreeze
un as in unbolt.
Im- is the correct prefix. This would make the word immature.
Hypo is the opposite of the prefix hyper.
The prefix "in" could be used to make the opposite word insufficient.
Comfort, dis being the prefix.
discomfort
uncomfortable
I'm preaty sure you would add dis- to make it discomfort
mesa
the prefix of counteract is opposite