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Alcohol. It is a CNS (central nervous system) depressant. this is a guess on what is the most used - but it seems like a logical one.

THC (marijuana) is not technically a CNS depressent - and i bet alcohol is still used more often. Though both chemicals have effects on the GABA system

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12y ago
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9y ago

Alcohol is a commonly abused nervous system depressant.

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6y ago

Opioids and those in the same class.

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Q: What is the most abused nervous system depressant?
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