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The first major problem occured before the flight; the Command Module (Ken Mattingly) pilot was grounded by flight doctors after being exposed to German Measles; Mattingly was not immune and it was considered too risky for him to fly. Mattingly was replaced by John Swigert. The most serious problem, of course, was the explosion of a fuel cell oxygen tank which made the service module too risky to use for the remainder of the mission.

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Q: What is the first problem Apollo 13 encountered?
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