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Reversal can be achieved by stopping warfarin or administration of vitamin K, fresh frozen plasma or coagulation factor concentrates such as prothrombin complex concentrate (PCC). Complete reversal of anticoagulation may be life-saving. Fresh frozen plasma (FFP) and vitamin K are most frequently administered. However, there are surprisingly few studies defining the optimum dose of these products and there are no randomized studies comparing the relative benefit and risk of coagulation factor concentrates versus fresh frozen plasma.

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15y ago
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15y ago

The antidote for coumadin is Vitamin K. Coumadin, also known as warfarin, is an oral anticoagulant which prevents the activation of precursors of Factors X, IX, VII, II and Proteins C and S in the coagulation cascade by preventing the activation of vitamin K by Vitamin K epoxide reductase. This prevents the formation of a fibrin clot. Giving vitamin K to a person on coumadin will allow the re-activation of these clotting factors and allow fibrin to be formed and stable clot to be produced.

Fresh frozen plasma is another "antidote" used to provide active clotting factors if bleeding is a problem and the patient is on coumadin.

Usually, however, if the person's INR is elevated and there is no active bleeding, we just tell them not to take coumadin for a couple of days and have their level rechecked.

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10y ago

Vitamin K is the main antidote for coumadin. Coumadin (sold as Warfarin), is used as a blood thinner and as rat poison. It interferes with the body's use of vitamin K, so increasing vitamin K would counteract it in the case of an overdose or poisoning.

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tarek ali

Lvl 2
4y ago

Coumadin, the brand name of warfarin, is an anticoagulant medication taken by patients who are prone to deep vein thrombosis (DVT) or other vascular disorders. Vitamin K, a fat-soluble vitamin that the body stores in limited quantities, is the antidote for Coumadin overdose

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Wiki User

11y ago

Vitamin K is the antidote for coumadin.

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Wiki User

13y ago

Vitamin K

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Wiki User

11y ago

vitamin k

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Anonymous

Lvl 1
3y ago

Mrd

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Q: What is the antadote for coumadin?
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