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Since phosphate groups have a negative charge, adding them to histone tails neutralizes them and probably reduces their affinity for DNA. It might contribute to transcription because it stimulates histone acetyltransferases which cause histone acetylation and enhance transcription.

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Q: What is role of histone phosphorylation?
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It provides electrons and protons.


What is the attachment of a phosphate group to a molecule called?

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