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A nonsense mutation is a genetic mutation in a DNA sequence that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid. DNA is a chain of many smaller molecules called nucleotides. During protein formation, DNA (or RNA) nucleotide sequences are read three nucleotides at a time in units called codons, and each codon corresponds to a specific amino acid or stop codon, which is also called nonsense codon because it does not code for an amino acid and instead signals the end of protein synthesis. Therefore, nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence. When the mutated sequence is translated into a protein, this premature stop codon results in the production of a shortened, and likely nonfunctional, protein.
Jaycee Emard
Wiki User
∙ 13y agoA point mutation is single change in a base of a sequence of DNA. This change can be a missense mutation where a different amino acid is transcribed due to the change in a base. However if a change in base results in a stop codon (nonsense mutation) then the sequence ends up being cut short.
Wiki User
∙ 10y agoIf a purine or pyrimidine nitrogenous base is replaced by another purine or pyrimidine , resulting mutation is called a nonsense mutation . Its effect may be small or drastic depending upon affected amino acid . Only on amino acid is changed as in sickle cell disease .
Wiki User
∙ 13y agoIt introduces a premature stop codon into the mRNA.
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What mutation stops translation of the mRNA?
The type of mutation that stops the translation of a protein is a nonsense mutation. This occurs when a base substitution (point mutation) results in a STOP codon and thus stops translation of the sequence into a protein.
What type of mutation will affect the largest number of proteins produces by an organism?
Chromosomal mutation
Which type of mutation results in abnormal acid sequence?
A point mutation causes a change in the amino acid sequence creating a new type of protein. The mutations are categorized functionally as nonsense, missense and silent mutations.
What is one of a mutation that produces a harmful trait?
Hemophilia.
How does a nonsense suppressor mutation prevent amber mutants from terminating their polypeptides prematurely?
The mutation alters a tRNA so that it reads the amber codon and inserts an amino acid.
What mutation causes the DNA replication to stop early?
Nonsense
Which mutation cannot occur in a tRNA encoding gene?
nonsense mutation
What are the types of mutations that can occur?
nonsense mutation, missense mutation, frameshift muation, deletion or addition mutation
What are the similarities of a nonsense mutation and a missense mutation?
Both nonsense and missense mutations are point mutations - meaning a single base has been substituted. The difference between the two is that a missense mutation results in an amino acid being replaced with a different amino acid, whereas a nonsense mutation results in a premature stop codon.
What mutation stops translation of the mRNA?
The type of mutation that stops the translation of a protein is a nonsense mutation. This occurs when a base substitution (point mutation) results in a STOP codon and thus stops translation of the sequence into a protein.
What kind of mutation will result from the mistake made during DNA replication in the nucleotide sequence?
a nonsense mutation
A point mutation that changes a codon specifying an amino acid into a stop codon is called a?
nonsense mutation
A mutation that causes antibiotic resistance in bacteria is a what mutation?
Missense mutation Nonsense mutation Frameshift insertion Frameshift deletion All may cause antibiotic resistance in bacteria
A change in the sequence of DNA that results in a protein that is too short?
Nonsense mutation
What is the difference between a nonsense mutation and a missense mutation?
Missense mutation: changes one sense codon to another, resulting in incorporation of amino acid.Nonsense mutation: changes a sense codon into a stop (or nonsense) codon, resulting in premature termination.
What type of mutation will affect the largest number of proteins produces by an organism?
Chromosomal mutation
Will a point mutation cause the cell to make an incomplete polypeptide if the mutation results in a stop codon?
Yes, a point mutation will cause the cell to make an incompelete polypeptide chain that is non-functional, if the mutation results in a stop codon. This type of a mutation is also called as the Nonsense Mutation.
