pKa=40
how do you calculate pKa
Selegiline and rasagiline are "monoamine oxidase B inhibitors" that have been used in treating Parkinson's disease. Selegiline will be metabolized to amphetamine and methamphetamine, and can subsequently lead to insomnia. On the other hand, rasagiline won't be metabolized and it's also more potent.
pKa=2.86
pKa = 15
It is around pKa=13
Doxofylline Pka value is about 9.8.
pKa (dissociation constant) is variable with temperature.
The pka of a protonated ether (the conjugate acid) is about -3.5
The pKa of sulfonic acid is < 0
pKa of methanol is 15.5 see this pdf for more information about pka-values: http://chemweb.unp.ac.za/chemistry/Physical_Data/pKa_compilation.pdf
pKa of drug can be determined from Handerson Hasselbatch equation., when conc. of salt become equal to acid i.e. at equivalence point when pH=pka then in H-H equn, pH=pka