It blocks the voltage-gated Na+ channels.
TTX (the poison in pufferfish) inhibits neurons that transmit sensory information to the brain. Since TTX prevents the generation of action potentials in sensory nerves, the ability of the neurons to transmit sensory information will be inhibited. This loss of sensory information would be experienced as a "numbness" in areas exposed to the toxin.
TTX Company was created in 1955-12.
TTX Company's motto is 'Forward thinking'.
The effect that caffeine has on neurons is to make them more sensitive to the effects of neurotransmitters. Caffeine lowers the threshold and makes the neurons more sensitive. This means it takes less of the neurotransmitter to affect another neuron.
TTX will block the response at R1 but have no effect at R2
Tetrodotoxin (TTX) is a natural inhibitor and blocks single sodium channels in an all-or-none manner.
They both decrease action potential duration, but TTX is the only one that decreases the maximum rate of depolarization.
Marijuana is considered agonistic- it enhances the effects of neurotransmitters.
See OUSL course TTX 5234
This ever get figured out?
Drugs can act in various regions of the brain to exert their effects.
See the wikipedia article on tetrodotoxin, TTX.