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A high platelet count can happen for many reasons, but there are two basic processes involved.

  • The cells within the bone marrow produce more platelets.
  • Less platelets are removed from the blood by the spleen.

This condition is known as thrombocytosis.

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13y ago
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15y ago

A. Thrombocytosis is the presence of high platelet counts in the blood, and can be either reactive or primary (also termed essential and caused by a myeloproliferative disease). Increase platelet counts can be due to a number of disease processes:

a. Essential (primary) * Essential thrombocytosis (a form of myeloproliferative disease * Other myeloproliferative disorders such as chronic myelogenous leukemia, polycythemia vera, myelofibrosis b. Reactive (secondary) * Inflammation * Surgery (which leads to an inflammatory state) * Hyposplenism (decreased breakdown due to decreased function of the spleen) * Hemorrhage and/or iron deficiency

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11y ago

Platelets are made in bone marrow, the tissue located inside of bones. Abnormally high platelet production may occur independently, for reasons that are not known (primary thrombocythemia), or as a symptom of another condition (secondary thrombocytosis).

Causes of high platelets in primary thrombocythemia-In this condition, the bone marrow makes too many platelets. This condition may be inherited. Causes of high platelets in secondary thrombocytosis-Thrombocytosis is the occurrence of high platelets as a symptom of another condition. A wide range of diseases and conditions may cause high platelets including:
  • Anemia (low red blood cell count)
  • Blood loss
  • Cancer
  • Chemotherapy
  • Chronic myelogenous leukemia (type of cancer that develops in the bone marrow, the soft tissue inside bones that helps form blood cells)
  • Infection
  • Inflammatory disorders such as Kawasaki disease (rare childhood disease that involves inflammation of the blood vessels)
  • Myelodysplasia (group of conditions in which the blood cells are abnormal in development or function)
  • Myelofibrosis (disorder that results in scar tissue in the bone marrow)
  • Polycythemia vera (rare bone marrow disorder causing excessive production of blood cells)
  • Reaction to certain medications, including steroids
  • Splenectomy (surgical removal of the spleen)
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8y ago

In many cases, there is no effect. In some cases it can cause abnormal clotting resulting a heart attack or a stroke. But there are causes associated with it including anemia, infection or cancer.

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10y ago

A few reasons a persons platelet count is high are spleen removal, infection, cancer, and rheumatoid Arthritis. In order to be sure what is causing the high platelet count, one should see their personal doctor.

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11y ago

It can be a blood disorder but most often it is either iron deficiency or a stress reaction.

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Q: What are the reasons for high platelet count?
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