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In a general sense, No. However, the interaction between these medications depends on the dosage of both. If you are taking both the lowest dosages of each medication - the interactions will just cause increased drowsiness. However, If you are taking High Dosages of either one, then yes.

Flexeril is a muscle relaxer. Zolpidem (Ambien) is a strong sleep aid used to treat insomnia and anxiety related sleep disorders. The most common side effect of both are Drowsiness. However, both are known to be CNS (Central Nervous System) depressants. Therefore, you should refrain from mixing the two without consulting with your prescribing Doctor or Pharmacist.

Warning: If you are taking both these medications, DO NOT drink Alcohol with them. Drinking Alcohol (another CNS Depressant) can cause respiratory failure; and ultimately death.

Warning: Do not drive or operate machinery under the influence of either medication until you know how they will effect you. You should not operate machinery if you've taken Zolpidem at all.

Warning: Consult your doctor before changing or abruptly stopping any of the medications you are currently taking.

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13y ago
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13y ago

It's bad to mix any drugs. Everyone responds differently. What would the point even be of taking a stimulant (actually classed with amphetamines) and combining it with a seditave and muscle relaxer? Exact opposites.

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Q: Is mixing flexeril and zolpidem a bad idea?
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