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Yes. Sedatives and tranquilizers should not be used with Benadryl. But I could locate no warnings about tylenol. Myself, I don't like taking stuff together unless I have no choice. So maybe take these two meds an hour or so apart, and not at the same time.

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13y ago
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12y ago

Below are the ingredients of Tylenol PM

Ingredients

Active Ingredient: Acetaminophen

Purpose: Pain reliever

Active Ingredient: Diphenhydramine HCl

Purpose: Nighttime sleep aid

Note: Diphenhydramine HCl is the active ingredient of Benadryl

Below is the like to this information

http://www.Tylenol.com/product_detail.jhtml?id=Tylenol/pain/prod_pm.inc&prod=subppm#

Note: there is a link to a page that lists warnings about this product.

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14y ago

of course you can take benadryl with morphine, because sometimes morphine can make you allergic and make you itch badly. So the benadryl to used to stop the itching, but i have to take morphine and benadryl everyday because of my sickle cell. But its safe to take both.

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12y ago

Yes. Benadryl helps the Motrin work better.

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11y ago

Not saying I'm a doctor but I've done it a few times and everything has been fine.

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15y ago

Yes. You can actually purchase Tylenol PM, which is simply Tylenol mixed with Benedryl.

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Q: Can you take Motrin and Benadryl together?
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