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Eventually, rectal suppositories should dissolve in the rectum. The exact time this takes will be stated on the medication form you're given with this prescription. If the suppository doesn't dissolve in a reasonable amount of time according to the material, you can remove it. If you do so, I'd call the pharmacy first, and ask them why their med isn't performing per spec.

However, I've never heard of this happening -- suppositories are really good at dissolving per plan. Make sure you're not just getting impatient :}.

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Q: How long should Hydrocortisone Rectal capsule stay in rectum for?
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