Tylenol (acetaminophen) will stay in your system up to 48 hours if you take therapeutic doses of around 1000mg. However, this depends on your liver and metabolites.
The half life is around 4-8 hours, so if you're worried about testing positive for it and want to be completely on the safe side, err to the side of 48 hours.
Tylenol does not stay in your body more than 8 or 9 hours at a time. If you are taking Tylenol PM regularly to fall asleep, you should consult a sleep specialist or doctor.
4-6 hrs
almost 24 hour.
Over the counter Tylenol is not a drug that will show up on a drug screen or drug test. However Tylenol with Codeine is a narcotic and will show up on a drug test. It will stay in your system for on average five days.
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