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From "Gibb JW, Bush L, Hanson GR. Exacerbation of methamphetamine-induced neurochemical deficits by melatonin. J Pharmacol Exp Ther. 1997;283:630-5." Melatonin may exacerbate the monoaminergic effects of amphetamine-related medications. Coadministration of melatonin with methamphetamine in animal studies resulted in increased dopaminergic and serotonergic stimulation. The mechanism for this effect is not known, but could potentially lead to increased central nervous system stimulation and resultant cardiac and neurologic toxicity. Because abuse of amphetamines causes insomnia, and melatonin might be self-administered to counteract this pharmacologic effect, this potential interaction could be clinically important.

An effect in animals doesn't necessarily mean an effect will be present in people (also, this study is for methamphetamine, which is related to Adderall, but not the same), but this is reason to be careful when thinking about combining the two.

[Different Answer] Do not do, adderall is a stimulant and melatonin helps you sleep, so you cannot combine the two.

Ask you doc when to take the melatonin, no doubt you are having trouble falling asleep from the adderall, do not take the adderall at least 6 hrs prior to bedtime it needs to wear off, your doc should prescribe you something to sleep.

[Different Answer] There have been studies proving that taking melatonin helps children who take adderall fall asleep. I've not seen anything for adults, or anything about doses, but this I did see.

[Different Answer] from butterflyinrain: I have an ADHD and i just now searching about this topic!. i take 20mg adderall everyday. and i couldn't sleep. gee! i love adderall but i hate it at the same time.

I do know that adderall and melatonin have the opposite effect. that when combine they could have an harmful effect. But i also do know that ADDERALL XR is taken by the morning upon awakening and Adderrall have the long effect of only 10-11 hours on an adult with a normal weight.

it only make sense that after 12 hours of taking adderall it is safe to take melatonin?.

but as of now i am still finding out how many hours melatonin stay in the system. and what is the long term effect of alternating two medicine at the same time. ill edit this reply once i find out.

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Q: How does melatonin interact with Adderall?
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