The evidence for it actually having a harmful effect is not what one might consider overwhelming, though a small percentage of people do have negative reactions (similar to, but not precisely like, an allergy) to it and some recent studies have suggested that it might be linked to hyperactivity in children (the evidence that it causes hyperactivity is weak to nonexistent; the evidence that it has an adverse impact on behavior of those who are already hyperactive is somewhat more substantial).
Some can be for instance tartrazine cancause migraines and blurred vision to some people especially asthmatics many also Believe there is a link between tartrazine and hyperactivity.
tartrazine
E102
E 102
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Tartazine is a food additive found in many foods. Some of the side effects of the additive are blurred vision, itchy skin, asthma, and clinical depression.
Tartrazine is E102 and is a yellow food colouring.tartrazine has been removed from most food and drink as it made children hyper active.
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lack of oxygen would be a harmful effect.
How can you help minimize the harmful effect of a typhoon