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Skelaxin and Flexeril are both muscle relaxants, therefore both act as depressants on the central nervous system. Unless it has been cleared with your doctor, it would be unwise to take both at the same time.

Make sure you remind your doctor or nurse practioner if you are also taking other depressants such as prescription pain relievers (Percocet, Vicodin..) including medications like Fioricet (Esgic, butalbital), which contain a barbiturate.

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15y ago
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13y ago

Yes, I take Prozac 20mg daily and Skelaxin 3-5x day. There are no negative interactions. Skelaxin, however is metabolized through the liver and you should avoid taking large amounts of it with other medications that are also metabolized through the liver (like Tylenol).

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13y ago

Yes, though they both can cause drowsiness. Therefore, you might want to see how the combination effects you before decide to drive or operate machinery.

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11y ago

Yes. First is muscle relaxant and second is Antibiotic and you can take them together.

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7y ago

Discuss this with your doctor or pharmacist.

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Q: Can you take skelaxin and elavil?
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