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It really depends on how much of both you are talking about.It is safe to take some Vicodin and then later on an hour or two later to take ONE baclofen BUT it would be dumb to take these at the same time seeing how they are both central nervous system depressants and could be seriously dangerous even fatal.

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Wiki User

11y ago
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Wiki User

10y ago

I have just been made to change my muscle relaxer from Carisoprodol (350mg 3x per day) because I also take Oxycodone (30mg, 1-2 every 4-6 hrs, max 6) and although I have never abused them and have taken them together for years, there seems to be something coming from DEA about the mix being a drug cocktail. I've tried Flexeril, Skelaxin, Methocarbamol and Zanaflex with no success prior to Carisoprodol. There are only a couple more that my Pain Management doctor knows of one of them being Baclofen. I filled my first prescription of Baclofen (20mg 2x per day) this past week, and have had strong adverse reactions three different times. I drifted off to sleep one evening in my recliner, and it took my husband 3 hours of shaking and yelling to wake me. Another time, I sat to take a break from chores feeling fully awake, and went to sleep. My husband called me about 1-1/2 hrs later from work 5 times in a row with the phone sitting right next to my ear, and it did not wake me. He had to come home early from work and vigorously wake me again as I slept through our 3 loud, barking dogs. The last time, I went to sleep in the recliner watching a movie with my husband. He said after I slept for 3 hours, he finally woke me, and had to pull me out of the chair because I would immediately fall back into a deep sleep. I've read that there is a stage of adjustment before the body acclimates to this new drug, but I never had such adverse reactions when using Carisoprodol with Oxycodone.

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13y ago

Yes you can, my dad has been taking vicodin and baclofen together for years. Baclofen is an opiate stimulant and a muscle relazer so it makes the vicodin a little bit stronger

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Shirley Welch

Lvl 1
2y ago
I have h

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10y ago

If your tolerance can support it , i dont reccomend taking full dosages of both , methocarbonal is muscle relaxor just use it a enchancer not a base high.

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Wiki User

11y ago

Yes, only in small doses since both are muscle relaxers. Dont drive or drink though. Don't use with other drugs.

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Q: Can you mix baclofen and Vicodin?
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