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Yes you can.

'Protection from' means the permanant can't be;

Damaged by what it is protected from,

Enchanted/Equipped by what it is protected from,

Blocked by whatever it is protected from, or

Targeted by whatever it is protected from.

Now Progenitus therefore can't be damaged, enchanted/equipped, blocked or targeted by anything - but non-targeting cards can still affect it. The first part of protection will still save it from non-targeted damage, but non-targeted destruction, or bounce, will be able to affect it. Wrath of God, and Damnation, are non-targeted destruction spells, and will work against it.

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Q: Can you kill 'Progenitus' using 'Damnation' or 'Wrath of God' in Magic the Gathering?
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