No. They're not even remotely close to being the same.
The two bullets are the same caliber but that is where the similarity ends. The M-16 bullet is about 3 times the length of a 22LR, completely different in shape, about 4 times the weight, etc. Also the cartridge used in the M-16 has more than 10 times the powder than a 22LR, giving much higher muzzle velocity.
The M16 assault rifle is chambered for the 5.56x45mm NATOintermediate rifle cartridge. It can also accept .223 Remington rounds.
There is no one answer- it depends on the rifle. They are generally less powerful than a full size battle rifle cartridge. The M16 rifle uses a 5.56mm bullet, the AK47 a 7.62mm bullet, etc.
A rifle that shoots a .22 caliber bullet.
No
22 hornet is a 22 calibre rifle. Most think of a 22 rifle as a rim fire rifle. But it shoots a 22 calibre bullet but the cartridge case that fires the bullet is no where near the same. The Hornet holds much more powder and is center fire.
No
Have it examined by a good gunsmith. This rifle use a .22 caliber bullet, long rifle.
No. Not even close.
Impossible to answer without more details. What range? What bullet weight? What barrel length?
Usually, no.
.22 long rifle.
.223 inches.